The small intestinal epithelium is composed of villi that extend into the lumen and are lined by differentiated, post-mitotic cell types, and the crypts of Lieberkühn that contain undifferentiated stem cells interspersed with Paneth cells and partially-differentiated transit amplifying cells. This barrier is lined by a single layer of columnar cells, responsible for transporting nutrients, protecting the underlying tissues and self-renewal. Death of these patients often results from breakdown of the intestinal mucosal barrier. Previous reports concluded that colic seconds old age as the leading cause of death in horses. Colic remains a major cause of morbidity and death in horses.
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